The kinetics of drug transfer from a buffered aqueous phase (compartment A) through a lipid phase (compartment B ) to another aqueous buffered phase (compartment C) are reported. These kinetics are obtained from an in vifm model system which in important respects mimics drug transfer during the abso
Drug partitioning II In Vitro model for drug absorption
β Scribed by James T. Doluisio; Joseph V. Swintosky
- Publisher
- John Wiley and Sons
- Year
- 1964
- Tongue
- English
- Weight
- 439 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-3549
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The purpose of this research is to simulate the in vivo performance of drugs with a wide range of solubility and permeability characteristics formulated as oral dosage forms. The absorption-disposition model was developed using a number of physiological parameters as well as in vitro permeability da
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