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Drug Identification through in vivo Screening of Chemical Libraries

✍ Scribed by Darren M. Brown; Maurizio Pellecchia; Erkki Ruoslahti

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
120 KB
Volume
5
Category
Article
ISSN
1439-4227

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✦ Synopsis

Specific cell-surface molecules can direct leukocytes and certain tumor cells to particular organs. [1Β±3] Recent work by our group has shown that peptides, selected by using the in vivo phage-screening approach, are also capable of mediating selective in vivo localization of phage to individual organs as well as tumors. [4Β±6] To develop our targeting technology beyond peptide-based systems, we investigated the feasibility of screening a chemical library to identify small molecules other than peptides that possess a preferential affinity for particular organs or tissues. As a proof of principle, we screened [a] Dr.

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