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ChemInform Abstract: Ti-Catalyzed Regio- and Enantioselective Synthesis of Unsaturated α-Amino Nitriles, Amides and Acids. Catalyst Identification Through Screening of Parallel Libraries.

✍ Scribed by James R. Porter; Wolfgang G. Wirschun; Kevin W. Kuntz; Marc L. Snapper; Hoveyda Amir H. Hoveyda Amir H.


Publisher
John Wiley and Sons
Year
2010
Weight
38 KB
Volume
31
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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nitriles nitriles (benzene compounds) Q 0520 ## 36 -111 Ti-Catalyzed Enantioselective Addition of Cyanide to Imines. A Practical Synthesis of Optically Pure α-Amino Acids. -An efficient asymmetric Ti-catalyzed addition of cyanide to imines is disclosed using modular tripeptide ligands (I) as chir