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ChemInform Abstract: Ti-Catalyzed Enantioselective Addition of Cyanide to Imines. A Practical Synthesis of Optically Pure α-Amino Acids.

✍ Scribed by Clinton A. Krueger; Kevin W. Kuntz; Carolyn D. Dzierba; Wolfgang G. Wirschun; John D. Gleason; Marc L. Snapper; Amir H. Hoveyda

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

nitriles nitriles (benzene compounds) Q 0520

36 -111

Ti-Catalyzed Enantioselective Addition of Cyanide to Imines. A Practical Synthesis of Optically Pure α-Amino Acids.

-An efficient asymmetric Ti-catalyzed addition of cyanide to imines is disclosed using modular tripeptide ligands (I) as chiral auxiliaries. In order to obtain good yields and high enantioselectivities it is required to slowly add (ca. 20 h) an alcohol additive to the reaction mixture. -(KRUEGER, CLINTON A.;

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