๐”– Bobbio Scriptorium
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Drug absorption VI: Water flux and drug absorption in an in situ rat gut preparation

โœ Scribed by S. Kojima; R. B. Smith; W. G. Crouthamel; J. T. Doluisio

Publisher
John Wiley and Sons
Year
1972
Tongue
English
Weight
423 KB
Volume
61
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

XIII) similar to IX of the classical mechanism except for saturation of the 5,6-bond, but it may be favored since 6-position attack by hydroxide ions on uracils and pyrimidine nucleosides is well documented (4, 6, 8). The resultant active intermediate (IX or XII) may deaminate (XI1 -. XIII -+ XIV + X or IX + X) to give a uracil derivative, X, or the cytosine ring may open to give a nonchromophoric compound, IX or XI1 ---* XI. The subsequent deamination and/or decarboxylation of this acyclic product makes this pathway irreversible. These postulated mechanisms of Scheme IV readily explain the parallel deamination of cytidine to uridine and its direct loss to a nonchromophoric product in agreement with Scheme 11.

REFERENCES

(1) E. R. Garrett, J. Amer. Chem. SOC., 82,827(1960).

(2) E.

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