๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Evaluation of drug absorption and presystemic metabolism using an in situ intestinal preparation

โœ Scribed by Karl A. Yorgey; J. Frederick Pritchard; Ned L. Renzi; Barry H. Dvorchik


Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
389 KB
Volume
75
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Drug absorption VI: Water flux and drug
โœ S. Kojima; R. B. Smith; W. G. Crouthamel; J. T. Doluisio ๐Ÿ“‚ Article ๐Ÿ“… 1972 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 423 KB

XIII) similar to IX of the classical mechanism except for saturation of the 5,6-bond, but it may be favored since 6-position attack by hydroxide ions on uracils and pyrimidine nucleosides is well documented (4, 6, 8). The resultant active intermediate (IX or XII) may deaminate (XI1 -. XIII -+ XIV +

Absorption barriers in the rat intestina
โœ Daniel R. Mudra; Ronald T. Borchardt ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 457 KB ๐Ÿ‘ 1 views

Modulation of intestinal drug absorption barriers can have a profound impact on the bioavailability of orally administered compounds. With its commonality of use as an absorption model, it is valuable to assess the role of such barriers in the rat intestinal mucosa. In the present study, atenolol an

Assessment of presystemic and systemic i
โœ Takashi Mizuma ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 99 KB

Although hepatic availability has been extensively studied to assess the oral bioavailability of drugs, intestinal availability has not, especially that related to conjugative metabolism (phase II metabolism). The present study assessed intestinal presystemic availability by integrating the reported

Evaluation of creatine transport using C
โœ Alekha K. Dash; Donald W. Miller; Han Huai-Yan; Joe Carnazzo; Jeffrey R. Stout ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 134 KB ๐Ÿ‘ 2 views

Creatine is a nutraceutical that has gained popularity in both well-trained and casual athletes for its performance-enhancing or ergogenic properties. The major disadvantages of creatine monohydrate formulations are poor solubility and oral bioavailability. In the present study, creatine transport w

Absorption barriers in the rat intestina
โœ Daniel R. Mudra; Ronald T. Borchardt ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 207 KB ๐Ÿ‘ 1 views

Modern drug discovery chemical libraries contain a large number of molecular entities exhibiting low aqueous solubility, often necessitating the inclusion of solubilizing agents in preclinical models of absorption or metabolism. The objective of the present study was to investigate the effects of se