We have found that water and organic solvents mixed at different proportions can give good to excellent yields and short reaction times for the Morita-Baylis-Hillman reaction. The present Letter details our findings in the Morita-Baylis-Hillman reaction between several aromatic aldehydes and methyl
Driving the Morita-Baylis-Hillman Reaction to a Multicomponent Organic Transformation
✍ Scribed by Guillouzic, Anne-Françoise; Montel, Sonia; Laborde, Coralie; Volle, Jean-Noël; Pirat, Jean-Luc; Virieux, David
- Book ID
- 125433963
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 591 KB
- Volume
- 2014
- Category
- Article
- ISSN
- 1434-193X
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The application of electronic structure calculations to a key transition state in the reaction manifold of the Morita-Baylis-Hillman reaction allows the design of two bis(thiourea) cocatalysts capable of accelerating this reaction through the hydrogen bond mediated recognition of both the nucleophil