A rationally designed cocatalyst for the Morita–Baylis–Hillman reaction

✍ Scribed by Charlotte E.S. Jones; Simon M. Turega; Matthew L. Clarke; Douglas Philp

• Book ID: 104095417
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 539 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.05.037

✦ Synopsis

The application of electronic structure calculations to a key transition state in the reaction manifold of the Morita-Baylis-Hillman reaction allows the design of two bis(thiourea) cocatalysts capable of accelerating this reaction through the hydrogen bond mediated recognition of both the nucleophile and the electrophile.