Doxorubicin pharmacokinetics: the effect of abnormal liver biochemistry tests
β Scribed by Christopher J. Twelves; Nicola A. Dobbs; Helen C. Gillies; Christopher A. James; Robert D. Rubens; Peter G. Harper
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 289 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
Doxorubicin is metabolized extensively to doxorubicinol by the ubiquitous aldoketoreductase enzymes. The extent of conversion to this alcohol metabolite is important since doxorubicinol may be the major contributor to cardiotoxicity. Aldoketoreductases are inhibited in vitro by phenytoin. The presen
Recent work has shown that colchicine may benefit patients with primary biliary or alcoholic cirrhosis. However, very little is known about its pharmacokinetics in the presence of impaired liver function. To study this w e examined the effects of three models of experimental liver dysfunction and on