Doxorubicin is metabolized extensively to doxorubicinol by the ubiquitous aldoketoreductase enzymes. The extent of conversion to this alcohol metabolite is important since doxorubicinol may be the major contributor to cardiotoxicity. Aldoketoreductases are inhibited in vitro by phenytoin. The presen
Effect of a low-protein diet on doxorubicin pharmacokinetics in the rabbit
โ Scribed by Barry J. Cusack; Stephan P. Young; Vicki L. Loseke; Michelle R. Hurty; Loring Beals; Richard D. Olson
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 485 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The influence of ranitidine on the pharmacokinetics and toxicity of doxorubicin was studied in six female New Zealand white rabbits. Plasma pharmacokinetic data were first obtained from rabbits given 3 mg/kg doxorubicin. After 1 month, the same rabbits were treated with ranitidine, 2.5 mg/kg or 25 m
## Abstract The interaction between indomethacin (IND) and methotrexate (MTX) was investigated in rabbits. The study was designed so as to evaluate the effect of IND (1 mg h^โ1^) during a continuous MTX infusion (1ยท2 mg kg^โ1^) over 240 min. IND was injected i.v. at hourly intervals after a steady