Doxorubicin-loaded solid lipid nanoparticles to overcome multidrug resistance in cancer therapy

✍ Scribed by Keon Wook Kang; Myung-Kwan Chun; Ok Kim; Robhash Kusam Subedi; Sang-Gun Ahn; Jung-Hoon Yoon; Hoo-Kyun Choi

• Book ID: 103849514
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 374 KB
• Volume: 6
• Category: Article
• ISSN: 1549-9634
• DOI: 10.1016/j.nano.2009.12.006

✦ Synopsis

In the present study we developed doxorubicin-loaded solid lipid nanoparticles (SLN-Dox) using biocompatible compounds, assessed the in vitro hemolytic effect, and examined their in vivo effects on drug retention and apoptosis intensity in P-glycoprotein-overexpressing MCF-7/ADR cells, a representative Dox-resistant breast cancer cell line. Our SLNs did not show hemolytic activity in human erythrocytes. In comparison with Dox, SLN-Dox efficiently enhanced apoptotic cell death through the higher accumulation of Dox in MCF-7/ADR cells. Therefore, SLN-Dox have potential to serve as a useful therapeutic approach to overcome the chemoresistance of adriamycin-resistant breast cancer.

From the Clinical Editor: Doxorubicin loaded solid lipid nanoparticles (SLN-Dox) were studied in a cell line representative of doxorubicin resistant breast cancer. The nanoparticles did not show hemolytic activity; furthermore, they efficiently enhanced apoptotic cell death through higher accumulation of doxorubicin in cancer cells. This approach may be viable in overcoming the chemoresistance of adriamycin resistant breast cancer.