Paclitaxel-Loaded Poly(n-butylcyanoacrylate) Nanoparticle Delivery System to Overcome Multidrug Resistance in Ovarian Cancer

Paclitaxel and ceramide co-administratio

Paclitaxel and ceramide co-administration in biodegradable polymeric nanoparticulate delivery system to overcome drug resistance in ovarian cancer

✍ Harikrishna Devalapally; Zhenfeng Duan; Michael V. Seiden; Mansoor M. Amiji 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 628 KB

## Abstract The objective of this study was to overcome drug resistance upon systemic administration of combination paclitaxel (PTX) and the apoptotic signaling molecule C~6~‐ceramide (CER) in biodegradable poly(ethylene oxide)‐modified poly(epsilon‐caprolactone (PEO‐PCL) nanoparticles. Subcutaneou