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Down syndrome: Phenotypic assessment of the segmental trisomic Ts65Dn mouse

โœ Scribed by Laura Toso; Irene Cameroni; Cecilia Schmidt; Daniel Abebe; Catherine Y. Spong

Book ID
113431804
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
88 KB
Volume
195
Category
Article
ISSN
1097-6868

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๐Ÿ“œ SIMILAR VOLUMES

Down syndrome mouse models Ts65Dn, Ts1Cj
Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes
โœ L.E. Olson; R.J. Roper; L.L. Baxter; E.J. Carlson; C.J. Epstein; R.H. Reeves ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 296 KB

## Abstract Two mouse models are widely used for Down syndrome (DS) research. The Ts65Dn mouse carries a small chromosome derived primarily from mouse chromosome 16, causing dosage imbalance for approximately half of human chromosome 21 orthologs. These mice have cerebellar pathology with direct pa