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Down-regulation of TGF- β 1 production restores immunogenicity in prostate cancer cells

✍ Scribed by Matthews, E; Yang, T; Janulis, L; Goodwin, S; Kundu, S D; Karpus, W J; Lee, C

Book ID
111724319
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
89 KB
Volume
83
Category
Article
ISSN
0007-0920

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Transforming growth factor-b (TGF-b1) is a potent negative regulator of cell growth that transduces signals through interactions with type I and II receptors. Abnormal expression and mutational alterations of these receptors have been observed in several human malignancies. In this study, we investi