Tumor progression and metastasis may result in part from the selection of cell clones competent for survival, invasion and growth at secondary sites and characterized by loss of growth inhibitory responses, acquisition of increased adhesiveness and enhanced motility and protease expression. Transfor
Osteoblast-derived TGFβ-1 modulates matrix degrading protease expression and activity in prostate cancer cells
✍ Scribed by Claudio Festuccia; Adriano Angelucci; Giovanni Luca Gravina; Ida Villanova; Anna Teti; Adriana Albini; Mauro Bologna
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 10 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0020-7136
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Prostate cancers (PRCAs) frequently metastasize to bone. We show here that this process is facilitated by osteoblastmediated tumor cell recruitment. Transforming growth factor-1 (TGF-1) is produced by osteoblasts in a latent form and is activated by proteases in a cell-dependent manner. This cytok
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