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Down-regulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis

✍ Scribed by Wei-Jun Liu; Jian-Fei Jiang; Dong Xiao; Jian Ding


Book ID
113993288
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
532 KB
Volume
64
Category
Article
ISSN
0006-2952

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The steady-state level of nucleophosmin/B23 mRNA decreased during berberine-induced (25 microg/ml, 24 to 96 hr) apoptosis of human leukemia HL-60 cells. A decline in telomerase activity was also observed in HL-60 cells treated with berberine. A stable clone of nucleophosmin/B23 overexpressed in HL-6