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Clofilium induces apoptosis of human promyelocytic leukemia (HL-60) cells via BCI-2 insensitive activation of caspase-3 protease

✍ Scribed by B.Y. Choi; Y.H. Cho; H.Y. Kim; K.H. Lee; G. Kong


Book ID
117667721
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
135 KB
Volume
35
Category
Article
ISSN
0959-8049

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Some widely used antidepressants such as imipramine, clomipramine, and citalopram have been found to possess antineoplastic effects. In the present study, these compounds were found to induce apoptotic cell death in human acute myeloid leukemia HL-60 cells. Apoptosis induced by the antidepressants w