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Double heterozygosity in the BRCA1 and BRCA2 genes in Italian family

✍ Scribed by Vietri, Maria Teresa; Molinari, Anna Maria; Caliendo, Gemma; De Paola, Maria Laura; Giovanna, D’Elia; Gambardella, Anna Laura; Petronella, Pasquale; Cioffi, Michele


Book ID
124090991
Publisher
Walter de Gruyter GmbH & Co. KG
Year
2013
Tongue
English
Weight
527 KB
Volume
51
Category
Article
ISSN
1434-6621

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Genomic rearrangements in the BRCA1 and
✍ Sylvie Mazoyer 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 1 views

## Communicated by Richard Wooster Mutations in the BRCA1 and BRCA2 genes predispose women to breast and ovarian cancer. BRCA1 and BRCA2 are 83 and 86 kb long, with coding sequences of 5.7 and 10.2 kb, scattered over 22 and 26 coding exons, respectively. The large majority of the alterations ident