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Dose of rofecoxib in colorectal cancer

✍ Scribed by José Francisco Noguera Aguilar; Isabel Amengual Antich; Juan José Pujol Tugores

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
35 KB
Volume
110
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Dear Sir,

We have read with interest the article of Becerra et al. 1 about the increased toxicity and lack of efficacy of rofecoxib in combination with chemotherapy in the treatment of metastatic colorectal cancer.

The dose of rofecoxib employed in their clinical study was 50 mg/day, with a reduction to 25 mg/day in 3 patients with digestive bleeding. With these doses, the potential reduction of carcinogenesis was not reached. There was even a lack in the response to conventional chemotherapy.

In our opinion, a dose of 50 mg/day of rofecoxib is insufficient. We have made experimental studies on OFA rats to look for the best dose of rofecoxib to prevent promotion and progression of colorectal cancer. Doses that we have found effective in the reduction and prevention of colic pharmacologically induced carcinogenesis were 1.25 mg/kg/day, 2.5 mg/kg/day and 3 mg/kg/day. The lowest effective dose in our studies was 1.25 mg/kg/day, and the best dose for carcinogenesis reduction was 2.5 and 3 mg/kg/day.

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