Dose-dependent pharmacokinetics and hepatobiliary transport of bromophenol blue in the beagle
β Scribed by Robert J. Wills; Gerald J. Yakatan; Robert S. Pearlman
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 538 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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## Abstract The pharmacokinetics of furosemide were investigated in the rat at doses of 10 and 40mg kg^β1^ corresponding to doses of 80 and 320 mg given to humans based on body surface area. A threeβcompartment open model with renal excretion taking place from the shallow peripheral compartment gav
Following the intravenous administration of bromophenol blue to beagle dogs, graphs of the biliary excretion rate versus time displayed drastic fluctuations which render them of little value for standard pharmacokinetic modeling purposes. It was shown that these fluctuations in excretion rate are hi