Dose-dependent pharmacokinetics and biliary excretion of bromophenol blue in the rat
β Scribed by Robert J. Wills; Randall B. Smith; Gerald J. Yakatan
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 583 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The objective of this investigation was to compare the observed biliary clearance (CL(b)) and % of dose excreted in the bile (PD(b)) of mitoxantrone with the predicted values obtained from quantitative structure pharmacokinetic relationship (QSPKR) models. Blood and bile samples were collected from
## Abstract The pharmacokinetics of furosemide were investigated in the rat at doses of 10 and 40mg kg^β1^ corresponding to doses of 80 and 320 mg given to humans based on body surface area. A threeβcompartment open model with renal excretion taking place from the shallow peripheral compartment gav
Following the intravenous administration of bromophenol blue to beagle dogs, graphs of the biliary excretion rate versus time displayed drastic fluctuations which render them of little value for standard pharmacokinetic modeling purposes. It was shown that these fluctuations in excretion rate are hi