Dose dependence of sister chromatid exchanges in human lymphocytes induced by in vitro α-particle irradiation
✍ Scribed by E. Schmid; H. Roos
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 120 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0301-634X
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This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m
## Objective: To evaluate the cytogenetic effects following the ingestion of high doses of arsenicals. ## Methods: Determination of the mean sister chromatid exchange (sce) frequency and the population of high-frequency cells (hfc, cells with a high sce frequency) in the peripheral blood lymphocy