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Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by l-BSO and apoptosis

✍ Scribed by Alan H Stokes; Denise Y Lewis; Lawrence H Lash; W.Gray Jerome III; Ken W Grant; Michael Aschner; Kent E Vrana

Book ID
118518997
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
398 KB
Volume
858
Category
Article
ISSN
0006-8993

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## Abstract Naphthalene is metabolized in the lung and liver to reactive intermediates by cytochrome P450 enzymes. These reactive species deplete glutathione, covalently bind to proteins, and cause necrosis in Clara cells of the lung. The importance of glutathione loss in naphthalene toxicity was i