𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Role of metabolic activation, covalent binding, and glutathione depletion in pulmonary toxicity produced by an impurity of malathion

✍ Scribed by T. Imamura; L. Hasegawa


Book ID
113206288
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
594 KB
Volume
72
Category
Article
ISSN
0041-008X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Prevention of naphthalene-induced pulmon
✍ A. J. Phimister; H. T. Nagasawa; A. R. Buckpitt; C. G. Plopper πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 243 KB

## Abstract Naphthalene is metabolized in the lung and liver to reactive intermediates by cytochrome P450 enzymes. These reactive species deplete glutathione, covalently bind to proteins, and cause necrosis in Clara cells of the lung. The importance of glutathione loss in naphthalene toxicity was i