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Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria

✍ Scribed by Montserrat Marı́; Jingxiang Bai; Arthur I Cederbaum

Book ID
114274960
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
481 KB
Volume
32
Category
Article
ISSN
0891-5849

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## Abstract Naphthalene is metabolized in the lung and liver to reactive intermediates by cytochrome P450 enzymes. These reactive species deplete glutathione, covalently bind to proteins, and cause necrosis in Clara cells of the lung. The importance of glutathione loss in naphthalene toxicity was i