We read with interest the article by Grevle and colleagues, 1 reporting in Norway an association between the variant allele A1 of the TaqI A restriction fragment length polymorphism (RFLP) located in the dopamine D2 receptor (DRD2) gene and Parkinson's disease (PD). Similar findings have been report
Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease
β Scribed by Eng-King Tan; Yanni Tan; Anthea Chai; Christopher Tan; Hui Shen; Sau-Ying Lum; Stephanie M.C. Fook-Cheong; Mei-Ling Teoh; Yuan Yih; Meng-Cheong Wong; Yi Zhao
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 248 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
In a case control study, we examined the association of DRD2 Taq1A and Taq1B polymorphisms and risk of PD, and evaluated the strength of linkage disequilibrium of the polymorphisms. The Taq1A and Taq1B polymorphisms were in strong linkage disequilibrium. There was, however, no significant association of the two polymorphisms with PD. Β© 2003 Movement Disorder Society
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