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Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease

✍ Scribed by Valtteri Kaasinen; Sargo Aalto; Kjell Någren; Juha O. Rinne

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
90 KB
Volume
19
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Novelty seeking is a temperament trait characterized by impulsiveness and exploratory behavior. Dopamine has been suggested to be the primary neurotransmitter modulator of novelty seeking, and in young healthy subjects, a correlation between increased novelty seeking and decreased insular cortical dopamine D~2~ receptor availability has been reported. The proposed link between dopamine deficiency and reduction in novelty seeking in Parkinson's disease is controversial. The present study examined whether a link between insular D~2~ receptor availability and novelty seeking can be replicated in Parkinson's disease patients. [^11^C]FLB 457 positron emission tomography imaging was carried out in 28 patients with Parkinson's disease, and the data were analyzed using voxel‐based statistical analysis. The results demonstrated a negative correlation between the novelty seeking score and the dopamine D~2~ availability bilaterally in the insular cortex (corrected P = 0.001; r = −0.74 [right hemisphere]; r = −0.66 [left hemisphere]). The results provide further support for a relationship between novelty seeking and insular D~2~ receptors. They indicate that the association is cross‐cultural, independent of age, and unaffected by dopaminergic degeneration. © 2004 Movement Disorder Society

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