A serine-to-cysteine mutation of dopamine D2 receptor at codon 311 (Cys311) was found to have higher frequency in schizophrenic patients than in normal controls in Japanese by Arinami et al. 11994: Lancet 343: 703-7041. The Cys311 allele was found to be associated with patients with younger ageof-on
Dopamine D2 receptor molecular variant and schizophrenia
✍ Scribed by MarkusM. Nöthen; Dieter Wildenauer; Sven Cichon; Margot Albus; Wolfgang Maier; Jürgen Minges; Dirk Lichtermann; Brigitta Bondy; Marcella Rietschel; Judith Körner; Rolf Fimmers; Peter Propping
- Book ID
- 118556118
- Publisher
- The Lancet
- Year
- 1994
- Tongue
- English
- Weight
- 334 KB
- Volume
- 343
- Category
- Article
- ISSN
- 0140-6736
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reported identifying one missense nucleotide mutation from C to G resulting in a substitution of serine with cysteine at codon 311 in the third intracellular loop of the dopamine D2 receptor in schizophrenics. Arinami et al. 119941 reported finding a positive association between the Cys311 variant a
The dopamine D2 receptor gene is a candidate gene for schizophrenia because the potency of certain neuroleptics correlates with their affinity for this receptor, Casecontrol studies in 291 schizophrenics, 78 patients with affective disorders, and 579 controls on an association of a molecular variant