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No association of dopamine D2 receptor molecular variant Cys311 and schizophrenia in Chinese patients

✍ Scribed by Chen, Chia-Hsiang; Chien, Shih-Hsiang; Hwu, Hai-Gwo

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
305 KB
Volume
67
Category
Article
ISSN
0148-7299

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✦ Synopsis

A serine-to-cysteine mutation of dopamine D2 receptor at codon 311 (Cys311) was found to have higher frequency in schizophrenic patients than in normal controls in Japanese by Arinami et al. 11994: Lancet 343: 703-7041. The Cys311 allele was found to be associated with patients with younger ageof-onset, positive family history, and more positive symptoms. To investigate the possible involvement of Cys311 in schizophrenia in the Chinese population, 114 unrelated Taiwanese Chinese schizophrenic patients with positive family history and 88 normal controls were genotyped for Cys311. Four patients and 5 normal controls were heterozygotes of Ser311/Cys311; no homozygotes of Cys311 were identified in either group. The allele frequencies of Cys311 in Chinese schizophrenic patients and normal controls were 2% and 3%, respectively. No significant difference was detected between the two groups. Our results do not support the argument that the Cys311 allele of DRDZ poses a genetic risk for certain types of schizophrenia in Chinese populations.

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