Dopamine D1and D2mediation of the discriminative stimulus properties ofd-amphetamine and cocaine
โ Scribed by P. M. Callahan; J. B. Appel; K. A. Cunningham
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 902 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0033-3158
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The purpose of the present study was to assess the role of dopamine D 1 and D 2 receptors in the discriminative stimulus properties of the atypical antipsychotic clozapine (CLZ). Two groups of rats were trained to discriminate either a moderate dose of clozapine (5.0 mg/kg) from vehicle or a high do
To investigate the role of D, dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 rag/ kg, IM) from saline. Administration of various doses of cocaine resulted