To investigate the role of D, dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 rag/ kg, IM) from saline. Administration of various doses of cocaine resulted
Effects of stimulation and blockade of dopamine receptor subtypes on the discriminative stimulus properties of cocaine
โ Scribed by Rita L. Barrett; James B. Appel
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 460 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0033-3158
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Rats were trained to discriminate cocaine, 10.0 mg/kg, using a two-lever operant procedure. Dose-effect data were determined for the substitution of cocaine, diethylpropion, methylphenidate, phenmetrazine, phentermine, and fenfluramine for the cocaine stimulus. All of these drugs, except fenfluramin