Dopamine agonists and valvular heart disease in patients with Parkinson's disease: evidence and mystery
β Scribed by Mitsutoshi Yamamoto; Tadahisa Uesugi
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 253 KB
- Volume
- 254
- Category
- Article
- ISSN
- 0340-5354
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Valvular heart disease, associated with ergot derivative dopamine agonists, has been reported in patients with Parkinson's disease (PD). There are few comparative studies on the frequency, severity, and dose dependency of valvular disease associated with ergot derivatives. We analyzed these factors
## Abstract Fibrotic valvular heart disease (VHD) has been reported in association with ergot dopamine agonists (DAs), but the current database is insufficient regarding clinical relevance and comparison to data on nonβergot DAs. We evaluated the effects of four DAs (pergolide, cabergoline, ropinir
## Abstract ## Objectives: Several observational studies suggest an association between treatment with ergolineβderived dopamine agonists and valvular regurgitation. In this article, we present an overview of the literature and conduct a metaβanalysis. ## Methods: Observational studies addressin