Domino 1,4-Addition/Carbocyclization Reaction through a Radical–Polar Crossover Reaction

✍ Scribed by Fabrice Denes; Fabrice Chemla; Jean F. Normant

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 130 KB
• Volume: 42
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200250474

✦ Synopsis

on the occasion of his 70th birthday

We have recently shown that 3,4-disubstituted 3-methoxycarbonylpyrrolidines 1 can be constructed diastereoselectively by carbocyclization [1] of the zinc enolates derived from b-Nallyl aminoesters 2 (Scheme 1, path A) or by the domino 1,4-