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Dominant role of copper in the kinetic stability of Cu/Zn superoxide dismutase

✍ Scribed by Sandra M. Lynch; Wilfredo Colón


Book ID
116292004
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
184 KB
Volume
340
Category
Article
ISSN
0006-291X

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✍ Fabio Polticelli; Andrea Battistoni; Peter O'Neill; Giuseppe Rotilio; Alessandro 📂 Article 📅 1998 🏛 Cold Spring Harbor Laboratory Press 🌐 English ⚖ 566 KB

## Abstract We have expressed and characterized a mutant of __Xenopus laevis__ Cu, Zn superoxide dismutase in which four highly conserved charged residues belonging to the electrostatic loop have been replaced by neutral side chains: Lys120 → Leu, Asp130 → Gln, Glu131 → Gln, and Lys134 → Thr. At lo