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Does the tuberous sclerosis complex include intracranial aneurysms?

✍ Scribed by A. Beltramello; Giovanni Puppini; Andrea Bricolo; Ivo Andrea Bergamo Andreis; Ghassan El-Dalati; Lucia Longa; Silvia Polidoro; Giorgio Zavarise; Pierluigi Marradi


Book ID
105943015
Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
327 KB
Volume
29
Category
Article
ISSN
0301-0449

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## Abstract Soon after proposing the β€œtwo‐hit” hypothesis for tumorigenesis, Knudson pursued further experimental validation of the concept by using a rat model of dominantly inherited renal tumor. Today, the Eker rat is one of the best characterized models of tuberous sclerosis complex (TSC) and h