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Does the timing of maternal toxicity reflect on the unborn offspring in a developmental toxicity study?

✍ Scribed by Peter Delille; Ellen Broeckx; Graham P. Bailey

Book ID
113875950
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
53 KB
Volume
32
Category
Article
ISSN
0890-6238

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## Abstract The role of maternal toxicity in lovastatin‐induced developmental toxicity in rats was examined in a series of studies. The first study administered lovastatin at 100, 200, 400, or 800 mg/kg/day (mkd) orally to mated rats from Gestation Day (GD) 6 through 20. Maternal toxicity was obser