✦ LIBER ✦

Does ceramide play a role in neural cell apoptosis?

✍ Scribed by Raja Goswami; Glyn Dawson

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 157 KB
Volume: 60
Category: Article
ISSN: 0360-4012
DOI: 10.1002/(sici)1097-4547(20000415)60:2<141::aid-jnr2>3.0.co;2-5

No coin nor oath required. For personal study only.

✦ Synopsis

Ceramide is a lipid second messenger, that is generated in response to stimulation of the cell death pathways by a number of ligands binding to surface receptors, growth factor withdrawal, treatment with chemotherapeutic agents, or high doses of ionizing radiation or oxidizing agents. Depending on the target cell, ceramide induces diverse biological responses including apoptosis, cellcycle arrest, differentiation, and also proliferation. In this review we consider the evidence for its role in apoptosis in cells of the nervous system.

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