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Does parkin play a role in the peripheral nervous system? A family report

✍ Scribed by Giovanni Abbruzzese; Simona Pigullo; Angelo Schenone; Emilia Bellone; Roberta Marchese; Emilio Di Maria; Luana Benedetti; Paola Ciotti; Lucilla Nobbio; Vincenzo Bonifati; Franco Ajmar; Paola Mandich

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
107 KB
Volume
19
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Two genes were identified for autosomal recessive forms of early onset Parkinson's disease: parkin and DJ‐1. We describe 2 siblings with EOPD due to parkin mutations and peripheral neuropathy, which presented as neuropathy with liability to pressure palsies (HNPP) in the index case. RT‐PCR experiments revealed that the parkin gene is expressed in sural nerves from both controls and patient with parkin‐related disease. Our findings support the view that parkin may play a role in the peripheral nervous system. © 2004 Movement Disorder Society

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