✦ LIBER ✦

Does hypophosphatemia play a role in acute liver failure?

✍ Scribed by James P. Knochel

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 248 KB
Volume: 9
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840090327

No coin nor oath required. For personal study only.

✦ Synopsis

This is the first record of hypophosphataemia in acute liver failure induced by paracetamol; it occurred in most of the patients and was severe (<0.3 mmol/l) in more than one third. At this level hypophosphataemia produces impaired oxygen transport and tissue hypoxia, abnormal leucocyte function, depressed platelet numbers and function, generalised muscle weakness,and disorder of the central nervous system; these are frequent complications of acute liver failure. The similarity of the effects of liver failure and hypophosphataemia on the central nervous system (irritability, muscle weakness, dysarthria, confusion, and coma) suggests that phosphate depletion may be important in hepatic encephalopathy, and a progressive defect of phosphate metabolism in brain tissue of patients with chronic liver disease was shown re- cently by nuclear magnetic resonance spectros-COPY.

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