Melt granulation in a high shear mixer:
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B Campisi; D Vojnovic; D Chicco; R Phan-Tan-Luu
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Article
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1999
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Elsevier Science
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English
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Melt granulation of a formulation of theophylline, containing lactose, microcrystalline cellulose and hydroxypropylmethylcellulose as excipients, was investigated in a 10 l high shear mixer as an alternative method to the wet granulation process, using polyethylene glycol 6000 as melting binder. The