Granule breakage phenomena in a high shear mixer; influence of process and formulation variables and consequences on granule homogeneity
β Scribed by Kaspar van den Dries; Onno M. de Vegt; Vincent Girard; Herman Vromans
- Book ID
- 114079848
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 337 KB
- Volume
- 133
- Category
- Article
- ISSN
- 0032-5910
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Melt granulation of a formulation of theophylline, containing lactose, microcrystalline cellulose and hydroxypropylmethylcellulose as excipients, was investigated in a 10 l high shear mixer as an alternative method to the wet granulation process, using polyethylene glycol 6000 as melting binder. The
## Abstract Surface tension and viscosity are the important properties of liquid binders affecting wet granulation processes. They could be used to control solids flow pattern and relative motion of particles for controlling wetting, granule growth, consolidation, and breakage. This study aims to i