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DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines

✍ Scribed by J Devon Roll; Ashley G Rivenbark; Wendell D Jones; William B Coleman

Book ID
119901980
Publisher
BioMed Central
Year
2008
Tongue
English
Weight
919 KB
Volume
7
Category
Article
ISSN
1476-4598

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The c-erbB-2 proto-oncogene is amplified in a high percentage of primary human breast tumors, suggesting that the overexpression of this gene may be involved in the development of human breast cancer. We have investigated five human breast tumor cell lines and have detected amplified c-erbB-2 gene c