✦ LIBER ✦

Overexpression of the c-erbB-2 protein in human breast tumor cell lines

✍ Scribed by Nancy E. Hynes; Heinz A. Gerber; Suzanne Saurer; Bernd Groner

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 459 KB
Volume: 39
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240390208

No coin nor oath required. For personal study only.

✦ Synopsis

The c-erbB-2 proto-oncogene is amplified in a high percentage of primary human breast tumors, suggesting that the overexpression of this gene may be involved in the development of human breast cancer. We have investigated five human breast tumor cell lines and have detected amplified c-erbB-2 gene copies in two of them. This amplification leads to overexpression of the c-erbB-2 protein. In addition, two other cell lines have elevated protein levels without gene amplification, suggesting that other mechanisms can lead to overexpression of the c-erbB-2 protein. These results are similar to those that we obtained during a study of primary breast tumors (Berger et al.: Cancer Res 48:1238-1243, 1988). These breast tumor cell lines should be useful for an analysis of c-erbB-2 expression and of the mechanisms that in some cases lead to overexpression.

📜 SIMILAR VOLUMES

Expression of c-erbB receptors, hereguli

Expression of c-erbB receptors, heregulin and oestrogen receptor in human breast cell lines

✍ Anna deFazio; Yoke-Eng Chiew; Rebecca L. Sini; Peter W. Janes; Robert L. Sutherl 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 327 KB 👁 2 views

Overexpression of the human major vault

Overexpression of the human major vault protein in astrocytic brain tumor cells

✍ Walter Berger; Sabine Spiegl-Kreinecker; Johanna Buchroithner; Leonilla Elbling; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 181 KB

Evidence has shown that the major human vault protein (MVP), which is identical to lung resistance-related protein (LRP), may be causally involved in a special type of multidrug resistance (MDR). The purpose of this study was to investigate the expression and cellular localization of MVP in cells de

c-erbB-2 protein overexpression and p53

c-erbB-2 protein overexpression and p53 immunoreaction in primary and recurrent breast cancer tissues

✍ Shimizu, Chikako; Fukutomi, Takashi; Tsuda, Hitoshi; Akashi-Tanaka, Sadako; Wata 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 2 views

Background and Objectives: We investigated whether expression levels of c-erbB-2 and p53 proteins in breast cancer tissues differ in primary and metastatic lesions. Methods: Immunohistochemical staining or sandwich enzyme immunoassay was used to determine expression levels of c-erbB-2 and p53 protei

Serum c-erbB-2 protein is a useful marke

Serum c-erbB-2 protein is a useful marker for monitoring tumor recurrence of the breast

✍ Shigeru Imoto; Noriaki Wada; Takahiro Hasebe; Atsushi Ochiai; Takashi Kitoh 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 131 KB 👁 1 views

## Abstract C‐__erb__B‐2 oncogene protein (ErbB‐2/HER‐2) overexpression is a prognostic marker of breast carcinoma. The purpose of this study was to evaluate serum ErbB‐2 for monitoring tumor recurrence of operable breast carcinoma patients. The subjects were 86 breast carcinoma patients with stage

Ectopic expression of the ErbB-3 binding

Ectopic expression of the ErbB-3 binding protein Ebp1 inhibits growth and induces differentiation of human breast cancer cell lines

✍ Tracy J. Lessor; Joo-Yeon Yoo; Xianmin Xia; Nicholas Woodford; Anne W. Hamburger 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 279 KB 👁 2 views

Ebp1, an ErbB-3 binding protein, translocates from the cytoplasm to the nucleus of human breast cancer cells after treatment with the ErbB-3 ligand, heregulin. The purpose of these studies was to examine the effects of ectopic expression of ebp1 on the biological properties of human ErbB-3-expressin

Enhanced sensitivity to tumor necrosis f

Enhanced sensitivity to tumor necrosis factor-α in doxorubicin-resistant tumor cell lines due to down-regulated c-erbB2

✍ Stefan Sleijfer; Johanna G. W. Asschert; Hetty Timmer-Bosscha; Nanno H. Mulder 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 124 KB

We have studied the relationship between tumor necrosis factor (TNF)-sensitivity and doxorubicin-resistance in our doxorubicin-resistant cell line panel consisting of the parental cell line GLC4 plus GLC4-Adr2x and GLC4-Adr350x with respective resistance factors of 2 and 350 compared with GLC4. At t