## Abstract The binding of ^125^I‐Tyr^4^ bombesin was investigated on plasma membranes of 8 human breast cancer cell lines and 2 long‐term cultures of normal human breast epithelial cells. Scatchard plots were compatible with high‐affinity, single‐site class of receptors in 3 cell lines (K~D~ of 0.
Epithelial Mesenchymal Transition Traits in Human Breast Cancer Cell Lines Parallel the CD44hi/CD24lo/-Stem Cell Phenotype in Human Breast Cancer
✍ Scribed by Tony Blick; Honor Hugo; Edwin Widodo; Mark Waltham; Cletus Pinto; Sendurai A. Mani; Robert A. Weinberg; Richard M. Neve; Marc E. Lenburg; Erik W. Thompson
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 746 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1083-3021
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MATERIAL AND METHODS ## Cell culture Out of 10 human breast-carcinoma cell lines studied, 6 were derived from metastatic carcinoma as follows: MCF7, T47D, ZR 75-1, SKBR3
## Abstract Epithelial cadherin (E‐cadherin) is a 120 kDa cell–cell adhesion molecule involved in the establishment of epithelial adherens junctions. It is connected to the actin cytoskeleton by adaptor proteins such as β‐catenin. Loss of E‐cadherin expression/function has been related to tumor pro