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DNA strand breaks, NAD metabolism, and programmed cell death

✍ Scribed by Dennis A. Carson; Shiro Seto; D.Bruce Wasson; Carlos J. Carrera

Book ID
115892006
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
599 KB
Volume
164
Category
Article
ISSN
0014-4827

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## Abstract DNA damage occurs in ischemia, excitotoxicity, inflammation, and other disorders that affect the central nervous system (CNS). Extensive DNA damage triggers cell death and in the mature CNS, this occurs primarily through activation of the poly(ADP‐ribose) polymerase‐1 (PARP‐1) cell deat