Using the harvesting method of synchronizing L cells, the relationship of RNA synthesis to DNA replication was studied by the use of selective inhibitors o, C RNA synthesis such as actinomycin D and chromomycin succinate. The synthesis of the early replicating DNA fraction is a process sensitive to
โฆ LIBER โฆ
DNA replication in synchronized cultured mammalian cells: III. Relative times of synthesis of mouse satellite and main band DNA
โ Scribed by A.M. Tobia; C.L. Schildkraut; J.J. Maio
- Book ID
- 115744325
- Publisher
- Elsevier Science
- Year
- 1971
- Weight
- 292 KB
- Volume
- 246
- Category
- Article
- ISSN
- 0005-2787
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## Abstract The replication of mouse satellite DNA was delayed when synchronized 3T3 cells were exposed to low concentrations of hydroxyurea during S phase. It appears that the onset of satellite replication is not a time dependent event, but instead requires that a certain amount of main band DNA
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