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DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome

✍ Scribed by M. G. Mattei; N. Philip; E. Passage; J. P. Moisan; J. L. Mandel; J. F. Mattei

Publisher: Springer
Year: 1985
Tongue: English
Weight: 978 KB
Volume: 69
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00293038

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✦ Synopsis

Recombinant plasmid clone B74 (also named D18S3) containing a human single-copy DNA segment of 6 kilobases (kb) was localized by in situ hybridization on band pl13 of chromosome 18. This probe was then used in cytogenetic diagnosis to identify precisely a small supernumerary chromosome as an isochromosome i(18p).

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