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Analysis of Chromosome Band Ip36 Alterations by Chromosomal In Situ Suppression Hybridization With a Microclone DNA Bank

✍ Scribed by Daniele Zink; Andreas Weith; Tommy Martinsson; Manfred Schwab

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 845 KB
Volume: 3
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870030514

No coin nor oath required. For personal study only.

✦ Synopsis

Alterations of the distal portion of chromosome I p are a recurrent abnormality of several types of human cancer. In this study we show that chromosomal in situ suppression hybridization with a regional lp36 D N A bank generated by microdissection and microcloning can be employed to detect translocations involving I p36.

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