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DNA methyltransferase Dnmt1 associates with histone deacetylase activity

✍ Scribed by Kouzarides, Tony; Fuks, François; Burgers, Wendy A.; Brehm, Alexander; Hughes-Davies, Luke

Book ID
109827406
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
294 KB
Volume
24
Category
Article
ISSN
1061-4036

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Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1
✍ Jharna Datta; Kalpana Ghoshal; Sudarshana M. Sharma; Shoji Tajima; Samson T. Jac 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 355 KB

## Abstract De novo DNA methyltransferases, Dnmt3a and 3b, were purified by fractionation of S‐100 extract from mouse lymphosarcoma cells through several chromatographic matrices followed by glycerol density gradient centrifugation. Dnmt3a was separated from Dnmt3b and Dnmt1 in the first column, Q‐