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DNA methylation and gene silencing in cancer

โœ Scribed by Baylin, Stephen B

Book ID
126661771
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
205 KB
Volume
2
Category
Article
ISSN
1743-4254

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Epigenetic silencing of the imprinted gene ZAC by DNA methylation is an early event in the progression of human ovarian cancer
โœ Tetsuya Kamikihara; Takahiro Arima; Kiyoko Kato; Takao Matsuda; Hidenori Kato; T ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 610 KB

## Abstract __ZAC__ is a paternally expressed, imprinted gene located on chromosome 6q24, within a region known to harbor a tumor suppressor gene for several types of neoplasia, including human ovarian cancer (HOC). We have failed to identify genetic mutations in the __ZAC__ gene in tumor material.